Sitting atop the hills represented in the Great Seal of Ohio, Ohio University – Chillicothe (OU-C) is a non-residential regional campus with an enrollment of more than 2,500 students. For more than 60 years, OU-C has remained devoted to its mission of preparing students for the challenges of tomorrow and providing service to Chillicothe and the surrounding region. Founded in 1946, OU-C is the first of Ohio University\'s regional campuses and the first regional campus in the state. It is located 45 miles (72 km) south of the state capital of Columbus.
The campus location and the long-time membership of the Ross County region allows OU-C to draw a unique mix of both traditional college students, young adults ages 18–22 who begin college directly out of high school, and \"new traditionals,\" adults who are pursuing a degree later in life, often after many years in of work experience. In addition, the campus offers a wide variety of course times and schedules, to allow students to take classes when at their own convenience.